High-performance xenograft read-sorting for DNA methylation analysis

Authors

Altendorfer, S., Zentgraf, J., Schmitz, J. E., Plass, C., Gerhauser, C., Rahmann, S.

Abstract

Xenograft sorting tools separate sequenced DNA reads by species. We have enhanced the computational method and tool Xengsort to enable efficient epigenetic profiling of patient-derived xenograft models; it now supports cytosine-converted whole genome or reduced-representation data. Benchmarking Xengsort against several established methods (ICRG, bamcmp, XenofilteR) revealed consistently high accuracy across tools, but Xengsort outperformed the other tools in computational efficiency due to its alignment-free design.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 13 Oct 2026.

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