LongVerse: verified AI agents for Nanopore and PacBio DNA methylation analysis

Authors

Liu, Y., Zhang, Q., Li, S.

Abstract

AI agents now run sequencing pipelines, but their outputs are checked by proxy, with rubrics or language-model judges. LongVerse turns one English sentence into haplotype-resolved DNA methylation from Nanopore or PacBio reads, through agents that read the data, supply arguments to a pinned pipeline and never write code. On HG002, a healthy reference genome, agent and human expert produced byte-identical calls (r = 1.000) that agreed with bisulfite sequencing (r = 0.943, 0.884), at $0.12 to $0.54 of conversation per run. A consensus agent that admits any per-site caller reduced error 10.7 percent against the best published caller.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 21 Oct 2026.

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