Neonatal T cell maternal microchimerism is common and associates with early pregnancy SARS2 vaccination

Authors

Weaver, J., Houck, J., Jiang, Y., Tobey, C., Wong, J., Shree, S., Harrington, W. E.

Abstract

The fetus acquires a graft of maternal cells in utero, known as maternal microchimerism (MMc), which may be enriched for T cells. However, little is known regarding the determinants of T cell trafficking into the fetus or regarding the prevalence of T cell MMc in healthy neonates. Using a closely followed cohort, we determined the association between maternal vaccination and acute infection and the detection of T cell MMc in cord blood, as measured using polymorphism-specific qPCR. We identified an association between early pregnancy SARS2 mRNA vaccination, a potent T cell stimulus, and increased detection of T cell MMc.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 29 Oct 2026.

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