Comparative transcriptomic analysis of intestinal Tuft cells reveals species selectivity of DCLK1 expression

Authors

Lu, V. B., Masse, K. E., Kirkwood, A. J.

Abstract

Intestinal tuft cells are an emerging class of cells under investigation for its potential role in colorectal cancer and inflammatory bowel disease. These cells are a rare population of cells within the intestinal epithelium, thus requiring the use of cell type markers to identify tuft cells for study. Mouse models have primarily targeted the Dclk1 gene to identify tuft cells; however, in human studies it has been more challenging to identify DCLK1 expression in the intestine. This rapid report aims to provide clarity on appropriate cell type markers to identify human intestinal tuft cells for study.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 31 Oct 2026.

Stats

1-terrible, 9-excellent. How would you rate this preprint? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.