Authors
Grinevich, D., Kompathoum, O., Li, J., Turissini, D. A., Kelly, P., Sutherland, M., Marin, S., Gomez, O. M., Benard, G., Shikanai-yasuda, M. A., Cocio, T. A., Vicentini, A. P., Pires de Camargo, Z., Messias Rodrigues, A., Hahn, R., Mota, B., Marques de Macedo, P., Almeida-Paes, R., Alvarado, P., Zancope-Oliveira, R. M., McEwen, J. G., Sepulveda, V. E., Teixeira, M. d. M., Matute, D. R.
Abstract
Paracoccidioides is a genus of dimorphic fungal pathogens endemic to Latin America. We generated long-read de novo assemblies for 11 isolates representing four species of the brasiliensis complex (P. brasiliensis, P. americana, P. restrepiensis, P. venezuelensis) and P. lutzii. These include the first complete telomere-to-telomere assemblies for P. brasiliensis (Pb18) and P. americana (Pb03), each with five chromosomes. Comparative analyses revealed chromosomal fusion and fission events distinguishing P. brasiliensis and P. americana, and a 90 kb tandem duplication in P. americana containing siderophore biosynthesis genes (sid1, sid3, sid4), a cluster of putative virulence factors. Mitochondrial genomes showed conserved gene order but a phylogenetic topology inconsistent with the nuclear tree, suggesting mitochondrial introgression between P. lutzii and P. venezuelensis. RNA transposable elements were enriched near telomeres, correlated with genome size, and most abundant in P. lutzii. These assemblies provide key resources for understanding genome evolution and introgression in Paracoccidioides.
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bioRxiv
The authors list and abstract were imported from bioRxiv on 04 Nov 2025.
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