Authors
Saleh, S., Bakri, N., Issa, K., Badawi, H., Al-Sadek, T., El Jammal, R., Awad, M., Obeid, M., Khraiche, M.
Abstract
Electrocorticography (ECoG) is a clinical gold standard for localizing epileptic foci and mapping brain activity, but current ECoG arrays are rigid, non-degradable, and require surgical removal. We present a fully inkjet-printed, ultraflexible and biodegradable ECoG platform fabricated through a rapid (<24 hr), low-temperature process enabled by photonic sintering. The resulting arrays achieve high electrode density (7.44 electrodes/mm2), low impedance (10.6+/-4.5k{Omega} at 1kHz), and excellent signal quality (28dB SNR), while conforming to cortical tissue without damage. In a rat epilepsy model, the arrays captured distinct stages of seizure activity and revealed spiral-like seizure propagation dynamics in vivo, an emergent spatiotemporal pattern previously undercharacterized at this scale. A 1D convolutional neural network trained on the recorded signals enabled real-time classification of seizure stages with >95% accuracy. Histology confirmed long-term biocompatibility, with no neuronal loss or gliosis after 30 days. This platform demonstrates a clinically relevant, scalable path toward implantable, explant-free neural interfaces for high-resolution, patient-specific monitoring and closed-loop neuromodulation.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 05 Nov 2025.
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