Authors
Kaiser, A., Anvari Vind, F., Duarte, J. M. N., Jelescu, I. O., Lin, Y., Yu, X., Widmaier, M., Wenz, D., Xin, L.
Abstract
We investigated dynamic changes in nicotinamide adenine dinucleotide (NAD+) metabolism in the human occipital lobe using ultra-high field 31P functional magnetic resonance spectroscopy (fMRS) at 7 Tesla. Twenty-five healthy volunteers (mean age 24 {+/-} 4 years, 10 female) performed a visual task alternating between fixation and flashing checkerboard stimuli. 31P MRS spectra were acquired from a visual cortex voxel functionally localized by prior fMRI. Linear mixed-effects modelling revealed a significant reduction in NAD+; concentrations during the first stimulation block, while no significant change was observed during the second block. No significant changes were observed for other high-energy phosphate metabolites (ATP, phosphocreatine, and inorganic phosphate), indicating specificity in the NAD+; response. Exploratory analyses, dividing the blocks in two halves, suggested further reductions in NAD+; and tNAD in the second halves of both stimulation blocks, though these trends were not statistically significant. Our findings demonstrate the feasibility of using fMRS at 7T to detect stimulus-induced dynamics in cerebral NAD+; metabolism in vivo, providing insights into the interplay between glycolysis and oxidative phosphorylation during neural activation.
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bioRxiv
The authors list and abstract were imported from bioRxiv on 05 Nov 2025.
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