Methyl Carnosate, a Carnosic Acid Derivative, Attenuates Osteoclastogenesis via Modulation of RANKL-Induced NF-κB Activity

Authors

Zhang, L., Xie, C., Bao, X., Tabandeh, M., Deepak, V.

Abstract

Excessive osteoclast activity underlies bone-destructive diseases including osteoporosis and rheumatoid arthritis. RANKL-induced NF-kB signaling represents a critical pathway driving osteoclastogenesis. Here, we report that methyl carnosate, a naturally occurring diterpene from rosemary, inhibits RANKL-induced osteoclastogenesis with an IC50 of 1.2 uM and displays greater potency than its parent compound, carnosic acid. Promoter-reporter analysis further indicates attenuation of RANKL-induced NF-kB activity. These findings identify methyl carnosate as a potential lead compound for the development of bone-protective therapeutics.

Preprint server: bioRxiv
The authors list and abstract were imported from bioRxiv on 17 Jan 2026.

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