Authors
Duhne, M., Gonzalez Montalvo, I., Zheng, C. S., Pelattini, L., Berke, J. D.
Abstract
Loss of striatal interneurons expressing parvalbumin (PV+) is associated with impulsive and uncontrolled behaviors, yet how these cells contribute to striatal information processing is poorly understood. We compared spiking of five identified neuron types in sensorimotor striatum, as unrestrained rats waited for a cue then performed brief, well-practiced actions. During waiting PV+ selectively increased firing, and their suppression increased premature movements. This indicated a role restraining actions, yet PV+ suppression during the cue instead retarded actions. Each action was accompanied by a rapid sequence of spiny projection neuron (SPN) spiking, including both direct and indirect pathways and overlaid by sequential PV+ firing. Pairs of PV+ and SPNs showed millisecond-level synchrony, and PV+ firing inhibited nearby SPNs ~2ms later. PV+ interneurons thus provide both broad restraint and precise sculpting of striatal output to achieve fluid, appropriately timed behavior.
Preprint server:
bioRxiv
The authors list and abstract were imported from bioRxiv on 10 Nov 2025.
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