Preprints

Created 12 Sep 2026

Causal variant underestimation is a major overlooked driver of sequence-to-function model underperformance

by Drusinsky, S., Pollard, K. S.

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Created 09 Sep 2026

A nucleolar assembly module integrates an ancestral isoaspartylase to safeguard ribosome biogenesis

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Created 08 Sep 2026

Cap-Independent Translation Regulation of VEGF Using CRISPR-dCas13d

by Kabir, M. L., Kodikara, S. G., AlRamel, N., Alfehaid, J., Pokhrel, P., Basu, S., Balci, H.

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Created 09 Sep 2026

Multimodal profiling establishes ovarian fibrosis as a measurable and targetable hallmark of human reproductive aging

by Hughes, L., Zaniker-Gomez, E., Devrukhar, P., Biswas, S., Trofimchuk, A., Atazhanova, T., Riley, J., Kleinhans, A., Zhang, M., Holm Nielsen, S., Karsdal, M., Stout, M., Babayev, E., Duncan, F.

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Created 09 Sep 2026

Inner-membrane transporter genotype shapes susceptibility to non-lytic antimicrobials and bacterial fitness in Escherichia coli

by Chang, E. D., Jurgensen Engberg, J. M., Franzyk, H., Loebner-Olesen, A., Frimodt-Moeller, J.

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Created 11 Sep 2026

GH1-HMGA proteins restrict RNA-directed DNA methylation and antagonize linker histone H1 at euchromatic transposable elements

by amiard, s., Feit, L., Edera, A., VANROBAYS, E., Simon, L., Dardalhon-Cumenal, D., en naimani, S., Lorkovic, Z. J., Berger, F., Barneche, F., Quadrana, L., tatout, c., Probst, A. V.

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Created 14 Sep 2026

Large Language Models Predict Human Social Behavior via Interpretable Mechanisms

by Ye, Y., Fang, Y., Gao, X., Kurtz-David, V., Hula, A., Fan, C., Long, T., Shen, B.

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Created 03 Oct 2026

Balancing receptor engagement and payload catalytic activity broadens the therapeutic window of immunotoxins

by Liang, H., Beilhartz, G. L., Wang, X., Zou, K., Cao, S. B., Melnyk, R. A.

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Created 08 Sep 2026

Conservation of Nuclear Receptor DAF-12 with Evidence for Ligand Diversification in Plant-Parasitic Nematodes

by Liu, Y., Fan, C.-W., Wang, Z., Wendt, G., Zacharias, L. G., McDonald, J. G., Li, Y., Shen, S.-Y., Xu, H. E., Collins, J. J., Kliewer, S. A., Mitchum, M. G., Mangelsdorf, D. J., Mathews, T. P.

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Created 11 Sep 2026

Habitat impacts the diversification of adhesive discs and skull shape in clingfishes

by Huie, J., Summers, A. P., Hall, K. C., Trnksii, T., Hannam, S. E., Voelker, G., Martinez, C., Conway, K. W.

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