Preprints

Created 18 Oct 2026

Order Matters: Ambient RNA correction confounds doublet detection in single-cell RNA sequencing

by Meier, M., Howitt, G., Grima, C. V., Dixit, G., King, H., Gubbels, L., Levi, E., Davies, K., Shanthikumar, S., Neeland, M. R., Maksimovic, J., Oshlack, A.

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Created 19 Oct 2026

RiboBridge couples RNA backbone generation to sequence design through a learned interaction topology

by Ma, Z., Zheng, Y.

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Created 21 Oct 2026

Reliable and Efficient Agentic Protein Design with Toolset Harnessing

by Butcher, J., Chen, J., Hunt, A., Haas, C. M., Dai, W., Sharma, S., Mitra, R., Salike, S., Koob, J., Muraishi, A., Li, Z., Pyles, H., Tyka, M. D., Bauer, M. S., Brent, R. I., Mittal, A., King, N. P., Baker, D.

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Created 17 Oct 2026

Nanopore sequencing reveals the DNA replication timing programme of the malaria parasite Plasmodium falciparum

by Huang, X., Berkemeier, F., Berners-Lee, R., Sherborne, K., Chapman, S. E., Merrick, C. J., Boemo, M. A.

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Created 27 Oct 2026

Design of full-length agonist and antagonist antibodies for hard targets

by Pythia Labs Team,, Aglietti, R. A., Ansari, R., Bowers, P. M., Buelles, T.-H., Chauvin, H., Duplay, T. M., El Hibouri, M., Jorda, J., Laniado, J., Malago, M. M. A., Meador, K., Polovina, A., Polyak, K., Sosna, J., Tacke, R., Yeates, T. O., Zanini, L.

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Created 28 Oct 2026

Building virtual cell dynamics that evolve with biological measurements

by Zhang, Z., Wang, Z., Tian, Q., Zhou, B., Zhou, T., Nie, Q., Zhou, P.

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Created 02 Nov 2026

Single-cell perturbation prediction near experimental reproducibility with GENESIS

by Conci, R., D'Ascenzo, D., Cultrera di Montesano, S., Raghavan, S., Winter, P. S., Van Allen, E. M., Crawford, L., Lotter, W.

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Created 01 Nov 2026

Bioactivity foundation model for hit identification and hit-to-lead optimization from sequence data

by Koh, H. Y., Koh, H. J. W., Zheng, Y., Naranbhai, V., Schmidt, D. F., Barthelemy, J., Chen, Y.-J., Nguyen, A. T. N., Pan, S., May, L. T., Webb, G. I.

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Created 20 Oct 2026

SRSF1 coordinates transcription and alternative splicing to modulate p53 and genome-maintenance

by Paz, S., Bisotto, E., Caputi, M.

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Created 23 Oct 2026

From Magnetosomes to Vesicles: LemA Proteins as Drivers of Bacterial Membrane Reorganization

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