Preprints

Created 09 Oct 2026

Flexible 3D multimodal organoid interface reveals functional subnetworks and coordinated circuit activity in cortical organoids

by Wilson, M. N., Kharitonova, E. K., Yeh, J., Lee, J., Hemaidan, S., Essig, S., Shi, M., Crain, C. W., Ramezani, M., Sun, F., Zhou, T., Surucu, I., Mortazavi, F., Cubukcu, E., Thunemann, M., Zeldich, E., Kuzum, D.

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Created 02 Oct 2026

Higher-order topology uncovers the multidimensional dynamics of naturalistic emotion

by Zaffina, L., Diano, M., Petruso, F., Preti, M. G., Amico, E., Morgenroth, E., Petri, G., Van De Ville, D., Vuilleumier, P., Santoro, A.

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Created 29 Sep 2026

Beta-lactam enhancement against methicillin-resistant Staphylococcus aureus by cell wall blockade is autolysis-dependent: a butyrolactone derivative as case in point

by Magdum, P. M., Grissom, J. N., Franey, B. T., Ullah, S., Abdelaziz, M. H., North, J., Sarkar, A.

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Created 26 Sep 2026

Lateralized dopaminergic neuron activity encodes goal-directed turning

by Miriyala, A., Waddell, S.

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Created 29 Sep 2026

NexuST: A Hierarchical Foundation Model for Spatial Transcriptomics

by Liu, H., Zhao, Q., Lin, L., Zou, Z., Cai, W., Sun, J., Zhou, Y., Alvarez, M. A., Gilmore, A., Rattray, M., Frangi, A. F., Zhou, H.

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Created 03 Oct 2026

Two functionally distinct amyloid-β intermediates link aggregation pathways to pathology in Alzheimer's disease

by Urbanek, A., Dear, A. J., Rhodes, D. P., Garland, E. F., Wareing, H. E., Baker, H. J., Molenkamp, W., Zhang, R., Chen, G., Abelein, A., Bell, S. M., Varela, J. A., Michaels, T., Highley, J. R., Meisl, G., Johansson, J., De, S.

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Created 03 Oct 2026

Proteostasis in Podocytes: Role of Cargo Receptor Surf4 and Collagen IV Trafficking

by Cybulsky, A. V., Papillon, J., Konde Bilogui, C.-L., Shih, R.

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Created 17 Oct 2026

A cold-adapted Cas9 nuclease from the deep ocean

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Created 12 Oct 2026

PeTFlow: Flow-Matching Based All-Atom Peptide Design through Side-Chain State Tokenization

by Deng, Q., Xu, M., Chen, H., Lei, J.

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Created 20 Oct 2026

Genetic modification of primary airway epithelial cell cultures defines MX1 as a barrier for zoonotic influenza A viruses in the human respiratory epithelium

by Stevers, K., Oliveira Esteves, B. I., Aguiar Moreira, E., Jordi, S., Laloli, L., Moscardelli, C., Licheri, M. F., Wettstein, D., Mescoli, A., Mwanga, M., Baltensperger, A. T., Oberholster, L., V'kovski, P., Zimmer, G., Dijkman, R.

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