Preprints

Created 21 Sep 2026

A self-limiting, TREM2-dependent anabolic program confers microglial resilience in Alzheimer's disease

by Lin, D., Atkinson, J. R., Wu, W., Chen, M., Jayasekara, S., Segal, B. M., Ma, A., Gao, J.

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Created 27 Sep 2026

Pop-Corn: Predicting Perturbation Phenotype Effects Across Single-Cell and Spatial Contexts

by Chen, J., Cui, Y., Shao, Y., Sun, N., Martinez, M. R.

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Created 27 Sep 2026

Integrative analysis of the MDM2 promoter switch and cellular lineage plasticity in colorectal cancer: a contrast between the autonomous-proliferation type (CIN/CMS2) and the environment-adaptive type (MSI/gastric metaplasia)

by Tsukui, T., Tsuda, K., Yao, R., Shin, K.

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Created 14 Sep 2026

Lipid nanoparticle induced model endosomal membrane disruption

by Pramanik, S., Vasudevan, A., Liang, Z., Karole, A., Berchel, M., Jaffres, P.-A., Eygeris, Y., Sahay, G.

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Created 16 Sep 2026

HeartVar: An LLM-Assisted Tool for Clinical Classification of Variants in Cardiovascular Disease Cohorts

by Thompson, J.-L., Das, D., Dunwoodie, S. L., Giannoulatou, E.

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Created 11 Sep 2026

AutoScreen: AI Co-Scientist System for Target Discovery in Functional Genomics

by Qu, Y., Liu, X., Wang, X., Chen, M., Luo, X., Lyu, L., Yin, M., Hui, J., Yin, D., Dinesh, R., Qiu, L., Huang, K., Wang, H., Tong, S., Cousins, H., Feng, R., Martinez, O., Zhang, J., Chen, T., Altman, R., Leskovec, J., Regev, A., Wang, M., Cong, L.

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Created 22 Sep 2026

Optically addressable and programmable spins in DNA

by Meng, K., Einholz, C., Krueger, L., Rosenow, M., Bucher, D.

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Created 15 Sep 2026

Oxidized phosphatidylinositol impairs lysosomal membrane repair to promote ferroptosis

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Created 16 Sep 2026

Multistate Enzyme Design Enables Efficient and Stereoselective Multistep Catalysis

by Pham, N. T. H., Guo, R., Garcia Jimenez, R. P., Hutton, A. E., Johannissen, L. O., Wehrstedt, J. A., Seifinoferest, B., Birch-Price, Z., Berreur, J., Hay, S., Thompson, M. C., Green, A. P., Chica, R. A.

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Created 10 Sep 2026

pH-Dependent Evolution of Delafloxacin and Ciprofloxacin Resistance in Pseudomonas aeruginosa from cystic fibrosis (CF) and non-CF-patients

by Ireddy, N., Bosch, A., Seth-Smith, H., Kohler, P., Babouee Flury, B.

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