About
Summary
I, Kumudesh Mishra, PhD from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India. My PhD viva has been successfully defended on 14th April 2016. I am looking for a promising Postdoctoral/Research Position that offers both a challenge and a good opportunity for my career growth. I have been working in the capacity of Senior Research Fellow awarded by Indian Council of Medical Research (ICMR) New Delhi. I hereby provide some information about my PhD thesis research work and various other research projects. My PhD thesis work particularly deals with to investigate the genetic association of growth factors/receptors polymorphisms with GBC. We have found significant association VEGF and PDGFB SNPs with GBC and published our research work in J Gastroenterol Hepatol. 2013; 28(10):1678-85 and Asian Pac J Cancer Prev.2015;16 (14):5647-54). Further we have performed protein expression analysis of VEGF, PDGFB and HER-2/neu by immuno-histo-chemistry (IHC) in GBC (manuscript under preparation). We are also working on to evaluate the mutation of KRAS, BRAF and PIK3CA in GBC by Real time quantitative polymerase chain reaction (RTqPCR) with high resolution melting curve analysis (HRM) and direct sequencing. These studies will provide prevalence of mutations in GBC, their behavior with the disease course and effect on conventional therapies and to design protocols for molecular targeted therapy. My research work was presented in various international/national conferences including XXXI World Congress of Internal Medicine Santiago Chile in 2012, 40th annual conference of Indian Society of Human Genetics (ISHG) Mumbai, India in 2015. I have expertise in the lab techniques including PCR techniques (RFLP, ARMS), gene and protein expression analysis by Real time PCR and Immuno-histo-chemistry (IHC) respectively, High Resolution Melting Curve (HRM) analysis and DNA sequencing. I have worked independently on various bioinformatics and statistical software packages including, Primer3, SPSS, PopGene, Arlequin, Graph pad etc.
I actively involved in designing and writing of various research projects related with gallbladder cancer have been sent to different funding agencies for extramural funding, data analysis, manuscript writing, and conference presentations.
My research area is gallbladder cancer and research interest to identify new diagnostic biomarkers for risk prediction/early diagnosis and drug target discovery for gallbladder cancer by applying genomics/ proteomics/transcriptomics.
Positions
PhD Student Sep 2012 - Apr 2016
I, Kumudesh Mishra, PhD from Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, UP, India. My PhD viva has been successfully defended on 14th April 2016. I am looking for a promising Postdoctoral/Research Position that offers both a challenge and a good opportunity for my career growth. I have been working in the capacity of Senior Research Fellow awarded by Indian Council of Medical Research (ICMR) New Delhi. I hereby provide some information about my PhD thesis research work and various other research projects. My PhD thesis work particularly deals with to investigate the genetic association of growth factors/receptors polymorphisms with GBC. We have found significant association VEGF and PDGFB SNPs with GBC and published our research work in J Gastroenterol Hepatol. 2013; 28(10):1678-85 and Asian Pac J Cancer Prev.2015;16 (14):5647-54). Further we have performed protein expression analysis of VEGF, PDGFB and HER-2/neu by immuno-histo-chemistry (IHC) in GBC (manuscript under preparation). We are also working on to evaluate the mutation of KRAS, BRAF and PIK3CA in GBC by Real time quantitative polymerase chain reaction (RTqPCR) with high resolution melting curve analysis (HRM) and direct sequencing. These studies will provide prevalence of mutations in GBC, their behavior with the disease course and effect on conventional therapies and to design protocols for molecular targeted therapy. My research work was presented in various international/national conferences including XXXI World Congress of Internal Medicine Santiago Chile in 2012, 40th annual conference of Indian Society of Human Genetics (ISHG) Mumbai, India in 2015. I have expertise in the lab techniques including PCR techniques (RFLP, ARMS), gene and protein expression analysis by Real time PCR and Immuno-histo-chemistry (IHC) respectively, High Resolution Melting Curve (HRM) analysis and DNA sequencing. I have worked independently on various bioinformatics and statistical software packages including, Primer3, SPSS, PopGene, Arlequin, Graph pad etc.
I actively involved in designing and writing of various research projects related with gallbladder cancer have been sent to different funding agencies for extramural funding, data analysis, manuscript writing, and conference presentations.
My research area is gallbladder cancer and research interest to identify new diagnostic biomarkers for risk prediction/early diagnosis and drug target discovery for gallbladder cancer by applying genomics/ proteomics/transcriptomics.
Education
Integral University, Lucknow, UP, India 2012 - 2016
Field of study: Molecular and Cancer Genetics
Degree: PhD
PhD thesis entitled “ Role of vascular endothelial growth factor (VEGF), platelet derived growth factor-B (PDGFB) and human epidermal growth factor receptor-2 (HER2) single nucleotide polymorphisms (SNPs) in gallbladder cancer (GBC)
Skills
I have expertise in the lab techniques including PCR techniques (RFLP, ARMS), gene and protein expression analysis by Real time PCR and Immuno-histo-chemistry (IHC) respectively, High Resolution Melting Curve (HRM) analysis and DNA sequencing. I have worked independently on various bioinformatics and statistical software packages including, Primer3, SPSS, PopGene, Arlequin, Graph pad etc.
I actively involved in designing and writing of various research projects related with gallbladder cancer have been sent to different funding agencies for extramural funding, data analysis, manuscript writing, and conference presentations.
Professional interests
Cancer Genetics, Cell Signaling, Drug targeted therapies, Genome wide association studies (GWAS)
Fellowships
Senior Research Fellowship 2011 - 2014
Awards
Travel grant to attend ASHG 2014 at San Diego USA form CSIR New Delhi 2014
Grants
Indian Council of Medical Research Senior Research Fellowship 2011 - 2014
Collaborations
Niigata University of Human Welfare, Niigata, Japan 2015 -
Association between mycotoxin concentrations and gallbladder cancer incidence in India.
Languages
English and Hindi
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