Laury NGUEMA

PhD student Oct 2021 - Dec 2025

Team ACCELERATES Godot, Vaccine Research Institute

Thesis subject: mechanisms of CD40-targeting subunit vaccine to induce anti-SARS-CoV-2 memory CD8+ T-cell responses

Designed and performed experiments on humanized NSG and transgenic hCD40 mouse models (bleeding, IP, IM, SC injections, spleen and lymph node collection), applied flow cytometry (cell staining, acquisition on spectral and conventional cytometers and data analysis), performed functional immune assays in BSL-2 laboratory (ELISpot, AIM, EpiMax), qPCR, ELISA, metabolism data analysis

Presented results during scientific meetings: CD40.SARS.CoV2 but not mRNA BNT162b2 vaccine stimulates selective enrichment in Spike- and Nucleocapsid-specific CD8+ stem cell-like memory T cells (poster communication, SFI Nice 2022), Generation of Tscm cells after anti-SARS-CoV-2 vaccination (oral communication, VRI Annual Meeting 2023)

Taught three courses in Master’s program in Immunity, Infection, Immunotherapy at UPEC

Published first author article: Subunit protein CD40.SARS.CoV2 vaccine induces SARS-CoV-2-specific stem cell-like memory CD8+ T cells (EBioMedicine, 2025, 111, 105479)

Published first author review: CD8+ Stem Cell-like Memory T Cells: Unveiling the Potential for Next-Generation Vaccination Strategies (Cell Reports Medicine, 2026, 7, 102990)

M2 Trainee Jan 2020 - Jun 2020

Team Work Package 1, Faculty of medicine

Trainee subject: potential interest of hyper-protein diet on strengthening of intestinal barrier in acute graft-versus-host disease (aGvHD) in mouse model

Experimentation on female wild type B6D2F1 mouse model (irradiation, collection of spleen, bone marrow and ileum), prepared grafts (stem and T cells), observated ileum histological cuts (size of villosities, depth of crypts and number of goblet cells)

M1 Trainee Apr 2019 - May 2019

Team Signaling, carrier state and bacterial virulence, INRAE Val de Loire

Trainee subject: functions of T3SS1 effectors in Salmonella Typhimurium in T3SS-1 independent cell model

Performed culture of bovine epithelial intestinal cells (IPEC-1), bacterial adhesion and invasion assays, bacterial transformation by electroporation, immunofluorescence, flux cytometry, Western Blot and end-point PCR

DETLM Trainee Oct 2016 - Dec 2016

Hormonology Laboratory, Cochin hospital

Performed ELISA to detect IGFBP-1 in amniotic fluids

Premature rupture of the membranes: comparative study of analytical evaluation of diagnostic tests (Annales de Biologie Clinique 2018 Vol 76 N°3 300-306)

Paris-Est Créteil University 2021 - 2025

Field of study: Molecular and Cellular Biology
Degree: PhD

Received a PhD scholarship from the Graduate School Health and Life Sciences by achieving an oral competition (July 2021)

Thesis defended on the 18th December 2025

PhD certificate awarded on the 27th March 2026

University of Tours 2018 - 2020

Field of study: Infectiology, Immunity, Vaccinology & Biopharmaceuticals
Degree: Master

Specialty Molecular and Cellular Infectiology

University of Tours 2016 - 2018

Field of study: Life Sciences
Degree: Bachelor

Institute for formation of medical laboratory technicians of Paris 2013 - 2016

Field of study: Biology
Degree: 2-year post-baccalaureate

French diploma of medical laboratory technician obtained