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Paul Bradfield

Paul Bradfield

Main current position is not set

  • Contribution score: 90
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About

Summary

I am a PhD MBA Scientist with over 15 years experience in medical research, drug discovery and business development. Previously, I was a Project Leader and LabHead responsible for developing novel translational techniques and strategic opportunities.

I am currently engaged in developing proprietary translational techniques using primary human cells and HT bio-imaging. These have been designed to accelerate the drug development process and provide solutions to common problems associated with species cross-reactivity, animal testing and understanding the relevance in human disease.

Positions

Scientific Collaborator Jun 2014 -

University of Geneva

  • Development of leukocyte recruitment models in chronic inflammatory disease, lymphomas and secondary metastases.
  • Development of proprietary bio-imaging technique for screening drug-like molecules on solid tumors
  • Construction, supervision and maintenance of multiple bio-imaging platforms

MBA Internship (Independent of position)

  • Start-up Entrepreneurial Business Plan - Hi-throughput bio-imaging platform service
  • Market Analysis – Identification and evaluation of specialised niche markets in translational medicine
  • Strategic Planning and Road Map- anticipated market developments and company progression
  • Financial and Investment Planning – Forecasts of profitability and cash flow projections

Business and Scientific Consultant Aug 2013 - May 2014

Geneva

  • Business Intelligence – Collation of data, provision of analysis reports and recommendations
  • Proofreading and writing of scientific documents and peer-reviewed articles
  • Advice and construction of specialist bio-imaging platforms

Senior Scientist Jul 2008 - Jan 2013

Geneva

  • Project Team Leader: Drug Discovery – Cross-functional
  • Leader of an International project team to develop a drug for treating Inflammatory disease
  • Project taken from concept to Lead Optimization - preparation for Early Development phase
  • Member of Joint Steering Committee - Coordinate team activities with an external collaborator
  • Filing of a patent for a therapeutic antibody developed by project team (See Appendix)
  • Identify bottleneck activities and propose mitigation strategies
  • Regular reviews of scientific literature – Highlight new developments in recently published journals, advise the team on potential impact on project progression and strategy
  • Regular updates to senior management on project status and resource requirement

 

  • Laboratory Head: Leukocyte trafficking, Neuroimmunology
  • Construction and development of a proprietary hi-throughput bio-imaging platform with multiple translational applications in chronic inflammation and oncology
  • Manager of three direct reports (2 technicians + 1 student) who run and maintain the facility
  • Organization of laboratory tours of the laboratory facility to external visitors and groups

 

  • Scientific Responsibilities
  • Review of in-licensing opportunities - preparation of due-diligence reports
  • Member of a global project team –Development of translational models to understand the mode-of-action of drugs in clinical development or already on the market
  • Proposal of drug targets - Identify drug targets of potential interest based on scientific literature

Senior Post-Doctoral Scientist Apr 2008 - Jun 2008

University of Geneva

  • Development of a porcine endothelial:NK cell model to address xenograft/transplant rejection

Post-Doctoral Research Scientist Jan 2002 - Dec 2007

University of Geneva

  • Supervision and management of the flow assay and bio-imaging facility
  • Extensive proofreading of theses, manuscripts and grant proposals
  • Successful research portfolio – multiple publication in high quality peer reviewed journals 

Research Associate Feb 1997 - Dec 2001

University of Birmingham

  • Completion of PhD in Rheumatology
  • Development of leukocyte retention translational models in human chronic inflammatory disease
  • Establishment and maintenance of a cell bank for primary human fibroblast cell lines

Scientific Officer May 1992 - Jan 1997

University of Oxford

  • General organizational tasks and maintenance of laboratory and tissue culture facility
  • Project support for molecular biology, tissue culture and protein expression techniques

Education

EPFL 2013 - 2014

Field of study: Management of Technology
Degree: Executive MBA

University of Birmingham 1998 - 2001

Field of study: Rheumatology
Degree: Ph.D.

Skills

Leadership & Management
• Project Leader of a cross-discipline team of senior scientists
• Laboratory Head of the bio-imaging flow platform facility
• Responsibility for staff training - Mentoring and supervision of post-graduate students

Business
• Business Intelligence and Strategy– data analysis and reporting
• Market analysis on pharmaceutical R&D and efficiency in drug development
• Benchmarking translational technologies against alternative strategies

Science
• Multiple publications in high quality peer-reviewed journals
• Development of hi-throughput propriet-ary translational techniques
• Extensive ‘hands-on’ experience in a wide range of scientific techniques

Communication
• Written reports provided for scientific and project review
• Ability to present complex data sets in a concise fashion
• Regular present-ations given to stakeholders, senior management and laymen audiences

Languages

English (mother tongue), French (conversational)

Additional information

Professional: PADI SCUBA Diving Instructor (Feb – Jul 2013)
Computers:   Extensive experience in Microsoft Office, Adobe After-Effects,
                    Photoshop, StatPlus, GraphPad Prism, Image-J

CV

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Contact details

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New opportunities

Open to new opportunities: Yes

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