Authors
Hannah Cole
Summary
Many respiratory toxicity identification methods have been established in the past, such as human research, and animal study. However, pulmonary research in humans is obviously limited due to the human and ethics issues; and for whole-animal inhalation studies, significant cost and time considerations are associated.
Nowadays, an improvement has been made by using three-dimensional (3D) human derived respiratory tissue model to predict the respiratory toxicity of compounds and chemicals. These tissues exhibits human relevant tissue structure and cellular morphology with high uniformity and reproducibility, and allows for in vitro respiratory toxicity testing of compounds such as pathogens, chemicals or therapeutics.
With over 10 years’ experience of working on cell & tissue products and services, Creative Bioarray provides in vitro airway tissue model and in vitro respiratory toxicity test to help chemical, personal care, and pharmaceutical industries to evaluate respiratory toxicity potential for their chemicals and products.
Introduction
In vitro 3D Models Available
In vitro airway tissue model
- Creative Bioarray's in vitro airway tissue model could be applied to in vitro respiratory toxicity testing, it is very similar to in vivo airway mucosa in terms of morphology, of differentiation markers and of functional characteristics.
Ex vivo airway tissue model
Respiratory cells and lung cells
Assays available
Cytotoxicity test: Assessment for the presence of leakage markers such as lactate dehydrogenase (LDH) or adenylate kinase (AK), two hallmark leakage markers.
Tissue viability test: MTT assay, WST-8 assay, and ATP content assay.
Histology assessment: Histological assessment of stained tissues is available, with focused viability determinations possible.
Contact us about your custom evaluation requirements.
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