Authors
Creative Bioarray
Summary
Musculoskeletal diseases include more than 150 confirmed conditions that affect the motor system. They range from short-lived problems (such as fractures, sprains, and strains) to lifelong conditions such as persistent pain and disability. The typical characteristics of musculoskeletal disorders are pain (usually persistent pain) and limited mobility and function.
Introduction
Creative Bioarray have an experienced pathology research team and advanced technology platform. Histological methods play an important role in discovering the characteristics of muscle and bone tissue, assessing disease development, and observing the healing of fractures and bone defects. We provide comprehensive services based on bone and muscle histopathology to support your research.
Materials
Bone histomorphometry describes the quantitative assessment of bone remodeling, modeling, and structure. It provides information that is not available from other investigative approaches, for example, bone densitometry and biochemical markers of bone turnover, and enables a more precise characterization of disease states and their response to treatment than can be obtained from qualitative examination of bone histology. Bone histomorphometry has been particularly valuable in determining the cellular pathophysiology of different forms of bone diseases and in defining the mechanisms by which drugs affect bone. In addition, it plays a central role in establishing the bone safety of drugs in humans. It can be applied either to bone histological sections or to high-resolution images produced by techniques such as microcomputed tomography and micromagnetic resonance imaging.
Structural and dynamic variables
Cancellous and cortical bone analyses
Defect or implant site healing
Procedure
Skeletal muscle is composed of muscle cells, fat cells, fibroblasts and other cell types. Multinucleated muscle cells are the main component of skeletal muscle and are also called muscle fibers (muscle fibers). Muscle histology research is a conventional method to study muscle function. Muscle function is determined by its structure and fiber type composition. According to different metabolic characteristics and the expression of myosin heavy chain (MyHC) subtypes, muscle fibers are divided into four types (I, IIa, IIx and IIb). Analysis of muscle fiber composition helps to study muscle metabolism and contraction function.
Myofiber density and number
Myofiber typing
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