Authors
Creative Bioarray
Summary
Immortalized cells are a population of cells from a multicellular organism due to mutation, which can escape normal cellular senescence and keep undergoing division. Thus, this kind of cells can grow in vitro for prolonged periods. The mutations required for immortality can occur naturally or be intentionally induced for experimental purposes. Immortal cell lines are a powerful tool for the biological investigator to research the biochemistry and cell biology of multicellular organisms, which plays an important role in the study of the biology of cell growth, differentiation, and senescence. And they have been applied in the research of cell biology, immunology, hematology, cancer biology, toxicology, and molecular biology.
Introduction
Firstly, primary cells will reach senescence after limited generation. The process of frequently re-establish fresh cultures from explanted tissue is tedious and it can also add significant variation from one preparation to another. Using immortalized cell can guarantee the experiment materials' consistent.
Next, in addition to the capacity of extended proliferation, the immortalized cells possess similar or identical genotype and phenotype to their parental tissue. Additionally, in many studies hTERT immortalized cells have been induced to become differentiated cell types, exhibiting tissue-specific features, differentiation-specific proteins, and forming structures that resemble those formed in vivo. All the mentioned above make immortalized cells become vital factor in cell biology research.
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