Authors
Yongzhe Li, Kunlin Zhang, Hua Chen, Fei Sun, Juanjuan Xu, Ziyan Wu, Ping Li, Liuyan Zhang, Yang Du, Haixia Luan, Xi Li, Lijun Wu, Hongbin Li, Huaxiang Wu, Xiangpei Li, Xiaomei Li, Xiao Zhang, Lu Gong, Lie Dai, Lingyun Sun, Xiaoxia Zuo, Jianhua Xu, Huiping Gong, Zhijun Li, Shengquan Tong, Min Wu, Xiaofeng Li, Weiguo Xiao, Guochun Wang, Ping Zhu, Min Shen, Shengyun Liu, Dongbao Zhao, Wei Liu, Yi Wang, Cibo Huang, Quan Jiang, Guijian Liu, Bin Liu, Shaoxian Hu, Wen Zhang, Zhuoli Zhang, Xin You, Mengtao Li, Weixin Hao, Cheng Zhao, Xiaomei Leng, Liqi Bi, Yongfu Wang, Fengxiao Zhang, Qun Shi, Wencheng Qi, Xuewu Zhang, Yuan Jia, Jinmei Su, Qin Li, Yong Hou, Qingjun Wu, Dong Xu, Wenjie Zheng, Miaojia Zhang, Qian Wang, Yunyun Fei, Xuan Zhang, Jing Li, Ying Jiang, Xinping Tian, Lidan Zhao, Li Wang, Bin Zhou, Yang Li, Yan Zhao, Xiaofeng Zeng, Jurg Ott, Jing Wang & Fengchun Zhang
Summary
Primary Sjögren’s syndrome is one of the most common autoimmune diseases. To identify novel genetic susceptibility loci for primary Sjögren’s syndrome, we performed a three-stage genome-wide association study (GWAS) in Han Chinese. At the discovery stage, 556,134 autosomal SNPs were analyzed in 542 cases and 1,050 controls. Promising associations were validated in two-stage replications with 1,303 cases and 2,727 controls. The combined analysis identified a new susceptibility locus for primary Sjögren’s syndrome. Our analysis also confirmed previously reported primary Sjögren’s syndrome associations in Europeans in several loci. Fine mapping of the region around the new locus confirmed the association and further extended the region of the new locus.Further details
The protocol was published on Protocol Exchange on 11 October 2013. To see the entire protocol, click on the source link.Advertisement
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