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Simple and scalable iodination of 2,6–dialkylanilines: useful building blocks for synthesis.

External protocol Created on 30 Apr 2014

Authors

Houssein Ibrahim, Clémentine Gibard, Audrey Hospital, Christelle Gaulier, Natasha Hewitt, Arnaud Gautier, and Federico Cisnetti

Summary

The syntesis of 2,6-dimethyl-4-iodoaniline and 2,6-diisopropyl-4-iodoanilne is described. Both compounds were easily obtained in using an aromatic iodination reaction with molecular iodine. The desired products were isolated in nearly quantitative yields after a simple extraction. The crude materials are pure according to NMR.

Further details

The protocol was published on Protocol Exchange on 4 December 2012. To see the entire protocol, click on the source link.

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