Authors
Nadja C. Bigall and Wolfgang J. Parak
Summary
In this protocol, a facile procedure for the transfer of quantum dots or different nanoparticles from organic synthesis into aqueous solution is described. Therefore, in the first step, poly(isobutylene maleic anhydride) is modified with hydrophobic side chains via amide bond formation. In the second step, this polymer is mixed with the nanoparticles and wrapped around them. The idea is let the side chains of the polymer intercalate with the inorganic ligands of the nanoparticles, and that the backbone of the polymer which is multifold charges due to the carboxylic groups leads to excellent water solubility. The nanoparticles are finally soluble in buffer solution and cleaned by gel electrophoresis or size exclusion chromatography. Additional functionalization of these nanoobjects is possible via amide bond formation.Further details
The protocol was published on Protocol Exchange on 28 August 2012. To see the entire protocol, click on the source link.Advertisement
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