Authors
Jinquan Yu
Summary
The most common bond in many organic compounds is the C–H bond. Hence, it is a great challenge to selectively cleave a particular C–H bond in the presence of multiple ones. One of most widely used approach to this problem is the use of -chelating directing groups1. However, the insertion of the transition metal is strictly restricted to the ortho-C–H bond through a six- or seven-membered cyclic pre-transition state (TS). Although many strategies have been developed to selectively functionalize meta- and para-C–H bonds2–4, this newly developed template approach overcomes the intrinsic steric and electronic bias of the substrates, and allows for the activation of remote C–H bonds.Further details
The protocol was published on Protocol Exchange on 29 June 2012. To see the entire protocol, click on the source link.Advertisement
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