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Synthesis of mono-6-tosyl-β-cyclodextrin, a key intermediate for the functional cyclodextrin derivatives

External protocol Created on 30 Apr 2014

Authors

Timothy Tan, Siu-choon Ng, Yong Wang, and Yin Xiao

Summary

Mono-6-tosyl-β-cyclodextrin (TsO-CD) is considered an important cyclodextrin (CD) intermediate for easy introduction of various functional groups such as halides, azide, amine and imidazole groups to afford functionalized CD derivatives. This protocol describes the use 1-(p-tosyl)-imidazole as the precursor to react with β-cyclodextrin, affording highly pure mono-substituted product with an acceptable yield.

Further details

The protocol was published on Protocol Exchange on 22 February 2011. To see the entire protocol, click on the source link.

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