Authors
Andreas Åslund, K. Peter Nilsson, and Peter Konradsson
Summary
Poly and oligo-thiophenes have previously been used for in vitro1,2, ex vivo3,4 and in vivo5 imaging of protein aggregates. The probe (p-FTAA) has been developed for the purpose of in vivo staining of protein aggregates such as amyloid deposits. It effectively passes the blood brain barrier and imaging can be performed live with two-photon imaging or ex vivo5. The straightforward synthesis of p-FTAA, including two Suzuki couplings, makes it an attractive probe for studies of most diseases involving protein aggregates.Further details
The protocol was published on Protocol Exchange on 26 January 2010. To see the entire protocol, click on the source link.Advertisement
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