Mass Spectrometry Imaging of Invisible Micro-Patterns on Graphene Substrate

Authors

Kun Qian, Chengzhong Yu

Summary

Invisible micro-patterns of trace amount molecules can be recognized through the mass spectrometry (MS) imaging technique on the engineered graphene film without additional chemicals such as organic matrix. The micro-patterns can be prepared in a controlled manner, where simple stamping was employed and diluted solution of molecules was used as the invisible ink. It is noted that due to the low concentration (pmol/µL) and detection of limit (fmol) for detection and imaging achieved in this protocol, the engineered graphene paper can be applied in not only tissue blotting for small metabolites and lipids molecules, but also forensic study to track trace amount of chemicals (such as drugs) in the latent fingerprint and record/monitor the invisible micro-pattern of specific molecules.

Further details

The protocol was published on Protocol Exchange on 12 March 2013. To see the entire protocol, click on the source link.

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