Authors
Henrik H. Jensen, Holger B. Kramer, and Benjamin G. Davis
Summary
Here we describe the efficient and facile synthesis of N-acetyl glucosamine propargyl O-glycoside, a compound which has been prepared previously by conventional methods.1 In previous syntheses the glycoside was obtained as a mixture of anomers1a) and in moderate to acceptable yield1b). The described improved method exploits a high yielding and strongly β-selective lanthanide triflate catalysed2 glycosylation reaction. In addition to reaction efficiency the method is characterised by its simplicity and facile compound isolation and purification. The propargyl O-glycoside was prepared for its subsequent use in Cu(I) catalysed protein modification reactions.3Further details
The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.Advertisement
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