Authors
Holger Kramer and Benjamin G. Davis
Summary
C-glycosides have received considerable attention in synthetic carbohydrate chemistry due to their unique features. As opposed to their natural congeners they are not prone to enzymatic or chemical hydrolysis. They can be prepared as anomerically pure glycosides and are isosteric to the heteroatom containing counterparts.1 Here we describe the synthesis of an alkynyl C-galactoside which was successfully employed in protein modification reactions by Cu(I) catalysed triazole formation.2 The syntheses of the corresponding C-glucoside3 and C-mannoside4 have been described previously in the literature.3,4Further details
The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.Advertisement
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