Authors
Holger Kramer and Benjamin G. Davis
Summary
Methanethiosulfonates (MTS) are a group of reagents which allow the site-selective modification of accessible cysteine residues in proteins.1 Synthesis of compounds carrying the MTS moiety has allowed the covalent attachment of structures to protein surfaces which represent functional mimics of post-translational modifications.2 Here we describe the synthesis of ethyl-linked O-glycosyl methanethiosulfates which allow the selective incorporation of fully deprotected carbohydrate structures onto protein scaffolds.3,4Further details
The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.Advertisement
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