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Assays of nucleosome assembly and the inhibition of histone acetyltransferase activity: 1. Assay of the inhibition of histone acetyltransferase (HAT) activity

External protocol Created on 03 May 2014

Authors

Takahito Yamasaki, Takehide Murata, Chunyuan Jin, Kohsuke Kato, Michiya Noguchi, Koji Nakade, Jianzhi Pan, Kyousuke Nagata, and Kazunari Yokoyama

Summary

We describe the protocol here using transcription factor JDP2 as a model protein with HAT-inhibitory and nucleosome-assembly activity. Filter-binding assays are performed as described elsewhere1 with minor modifications (see Figure 1a). For a detailed introduction to assays of nucleosome assembly and the inhibition of histone acetyltransferase activity, please go here: http://www.natureprotocols.com/2007/07/30/assays_of_nucleosome_assembly.php

Further details

The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.

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