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Detection of L- and E-selectin ligand by ligand blotting using L- and E-selectin-IgM chimeric proteins

External protocol Created on 03 May 2014

Authors

Junya Mitoma and Xingfeng Bao

Summary

Selectin-IgM chimeric proteins are commonly used to detect selectin ligands on tissue sections or cultured cells. There is no report to detect the ligands on membrane blot. Here we describe about ligand blotting using mouse E-selectin-IgM and L-selectin-IgM. E-selectin-IgM blotting is easier than L-selectin IgM blotting probably because of the higher affinity of E-selectin and its ligand.

Further details

The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.

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