Authors
Valérie Doyère
Summary
Pavlovian fear conditioning is a paradigm in which an initially neutral stimulus such as a tone (conditioned stimulus, CS) acquires aversive properties and comes to elicit fear responses through its pairing with an aversive unconditioned stimulus (US), such as an electrical foot shock. In a typical reconsolidation experiment, a single CS is presented the day after training in the presence of a pharmacological agent aimed at disrupting the cellular machinery involved in reconsolidation processes. Post-reactivation short-term memory (PR-STM) is then tested shortly after the retrieval (within 1-4 hours) and post-reactivation long-term memory (PR-LTM) is tested 24 hours later. Intact performance at PR-STM but impaired at PR-LTM indicates disruption of time-dependent reconsolidation processes. Here we developed a new protocol in which two conditioned stimuli (CS) were used, one to be reactivated (CSr), the other not (Csn).Further details
The protocol was published on Protocol Exchange in 2007. To see the entire protocol, click on the source link.Advertisement
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