Authors
Creative Biogene
Summary
Automated patch clamp is an important part of our services for institutes and drug discovery companies. Acroscell has a group of experienced scientists with decades of electrophysiological work experience. High-throughput detection can be achieved on the premise of accurate measurement, and 16 cells can be simultaneously detected each time. Our automated planar patch-clamp method on genetically modified mammalian cell lines for voltage- and ligand-gated ion channels as well as temperature-activated channels can be reached in gigaseal quality.
Besides providing a better support in drug discovery (ion channel screening), Acroscell meets higher throughput demands of early hERG risk assessment. We performed hERG safety evaluation in a GLP-compliant standard process with indicators qualified for new drug declaration. Over hundreds of compounds have been tested in our automated patch-clamp system.
Introduction
The Qube 384 and QPatch 16 of Sophion's high throughput screening system covers a wide range of throughput needs and provide the user with genuine whole-cell patch clamp data based on true gigaseals. Both can be used on almost any ion channel target. These are fully automated patch-clamp platforms that allow for the testing of up to 48 and 16 cells in parallel, respectively. These become our ways of making ion channel research easy, confirming hits from larger screens and also for lead optimization.
The QPatch machines offer high quality measurements with the formation of gigaohm seals. The platform can be used to assay both voltage-gated and ligand-gated channels and utilizes stable cell lines.
Advantages
Meeting the higher throughput demands of ion channel screening and early hERG risk assessment
Combined with our long-standing expertise in ion channel research and automation of electrophysiological assays, we offer high quality ion channel screening together with a careful data analysis and thorough data interpretation
Screening on other voltage-gated and ligand-gated targets
Positive control and vehicle control in every assay
Single concentration profiling and full concentration response curves
Applications
hERG screening service:Proven benchmark platform for cardiac safety.
Compound profiling against hERG to evaluate potential cardiac liability.
Detect hERG-related safety issues at early stages in the drug development process.
Screening on other voltage-gated and ligand-gated targetsBoth Current clamp and voltage clamp available.
QPatch outsourcing service
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