Authors
Hannah Cole
Summary
Acroscell is experienced in epilepsy research with keeping many mouse models of epilepsy caused by of ion channel genes mutations. Both multiple genes mutations and single-gene perturbations induced epilepsy models are available in Acroscell. Our large variety of mouse models can help researchers in understanding epilepsy and drug therapy in epilepsy disorders. These models also help us to discover the genes that cause epilepsy in human patients as well as those genes that have an effect on our susceptibility to seizures.
Introduction
Epilepsy disorders, also known as seizure disorders, characterized by chronically recurring seizures without clear precipitants. The term epilepsy refers to a spectrum of brain disorders resulting from a disturbance of the normal pattern of neuron activity. As a group of disorders, it is one of the most common diseases of the nervous system: the age-adjusted prevalence of epilepsy is in the range of 4 to 10 per 1000 people in most locations. While its diverse manifestations and causes demonstrate the complex nature of accurately diagnosing and treating any one form of epilepsy.
Epilepsy brings great burden to both the individuals with epilepsy and society. Because the diverse causes of epileptic disorders, the effectiveness of the available therapies (including drug therapy, diet therapy and nerve stimulation) varies significantly from patient to patient. In order to develop new medications, it is necessary to utilize experimental animal models of epilepsy. For example, chemically-induced kindling with pentylenetetrazole (PTZ) or electrically-induced seizures can be used a model of epilepsy. Identifying mouse models that recapitulate human epilepsies helps researchers in understanding of anticonvulsant drugs.
References
Giblin KA, Blumenfeld H. Is epilepsy a preventable disorder? New evidence from animal models. Neuroscientist. 2010; 16: 253–275.
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