Authors
Hannah Cole
Summary
The total disease burden for neuropsychiatric disorders in the European Union has been recently calculated as 30.1% in women and 23.4% in men. These psychiatric disorders can be categorized into: Schizophrenia, Bipolar disorder, Depression, Anxiety, Psychosis, etc. Animal models have been widely employed for the investigation of the neurobiology of psychiatric disorders and the discovery of new treatments.
Introduction
Acroscell has a wealth of experience in providing first-class preclinical translational research into the study, treatment and prevention of mental disorders, and we also put efforts in developing precisely tailored research packages to target out client's needs. No matter it is in vitro or in vivo molecular biology techniques, electrophysiological approaches or whole animal behavior studies, our research experts will provide professional consultancy in putting together your study proposal, and also rapidly deliver data of the highest quality to drive forward your research programs.
Materials
Bipolar disorder
Bipolar disorder is a brain disease associated with severe mood swings characterized by mania, depression and in severe cases, psychosis. The treatment to bipolar disorders mainly focuses on symptoms control. In humans, the anti-convulsant drugs valproate and carbamazepine are often used as mood stabilizers for treating acute manic episodes. Besides, lithium is used to treat acute episodes but also to prevent recurrent episodes of illness.
Anxiety
Anxiety is a general term for several disorders that cause nervousness, fear, apprehension and worrying. These disorders affect one's feeling and behaviors manifesting in real physical symptoms. Acroscell conducts contract studies in mice using the marble burying task to assess the efficacy of novel anti-anxiety compounds, such as anxiolytics and selective serotonin reuptake inhibitors (SSRIs).
Marble burying test
Marble burying behavior are adopted for evaluation of the level of anxiety in a mouse when it encounters unfamiliar objects. Marbles are placed evenly onto the walls of an empty cage and the mouse is treated with the vehicle or compound before the test (before placed in the cage containing the marbles). The test result is evaluated by the number of marbles discovered (at least 2/3 of area) and the animal behavior by photographing the test cage.
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