Probiotics as a targeted intervention in anti-aging: A review.

Authors

Fengcui Shi, Jingwen Peng, Haojin Li, Denghai Liu, Li Han, Ying Wang, Qingli Liu, Qian Liu

Published in

Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. Pages 1-35. Nov 01, 2024. Epub Nov 01, 2024.

Abstract

The age-induced disruption of gut flora, termed gut dysbiosis, is intimately tied to compromised immune function, augmented oxidative stress, and a spectrum of age-linked disorders. This review examines the fundamental mechanisms employed by probiotic strains to modulate gut microbiota composition and metabolic profiles, mitigate cognitive decline via the gut-brain axis, modulate gene transcription, and alleviate inflammatory responses and oxidative stress. We elucidate the capacity of probiotics as a precision intervention to restore gut microbiome homeostasis and alleviate age-related conditions, thereby offering a theoretical framework for probiotics to decelerate aging, manage age-related diseases, and elevate quality of life.

PMID:
39484861
Bibliographic data and abstract were imported from PubMed on 01 Nov 2024.

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