A new diphenyl ether with insecticidal activity from the mangrove endophytic fungus Aspergillus sp. GXNU-DY2-12.

Authors

Meijing Tan, Shichao Ju, Fan He, Wenjun Li, Youquan Wei, Weifeng Xu, Ruiyun Yang, Xishan Huang

Published in

Natural product research. Pages 1-9. Mar 07, 2025. Epub Mar 07, 2025.

Abstract

A new diphenyl ether pseudopithoether C (1), and five known compounds (2-6) were purified from secondary metabolites of the Aspergillus sp. GXNU-DY2-12 cultured in the rice medium. The new structure was analysed by NMR, HR-ESI-MS, and X-ray single crystal diffractometer. Compound 1 showed potent acetylcholinesterase (AChE) - inhibiting activity and its IC₅₀ value was 1.02 μM. Notably, it demonstrated remarkable insecticidal efficacy against Diaphorina citri Kuwayama, achieving a mortality rate of 88% under standardised bioassay conditions.

PMID:
40053830
Bibliographic data and abstract were imported from PubMed on 08 Mar 2025.

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