Ruthenium-Catalyzed Asymmetric trans-Selective Hydrogenation of 2,3-Disubstituted Quinoxaline Derivatives.

Authors

Zeyu Li, Wei Hao, Yuping Tang, Yan-Mei He, Qing-Hua Fan

Published in

Organic letters. Mar 11, 2025. Epub Mar 11, 2025.

Abstract

The asymmetric trans-selective hydrogenation of arenes has long been a significant challenge. In this work, we were able to control the trans/cis selectivity in ruthenium-catalyzed asymmetric hydrogenation of 2,3-disubstituted quinoxalines by varying the catalyst counteranion. Using density functional theory calculations, we investigated the weak interactions─such as CH/π and hydrogen bonding─among the counteranion, the catalyst framework, and the substrate, elucidating the fundamental influence of counteranions on trans/cis selectivity in the asymmetric hydrogenation of quinoxalines.

PMID:
40066497
Bibliographic data and abstract were imported from PubMed on 11 Mar 2025.

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