Divergent [5 + 1] Annulation of o-Aminobenzamides with Vinylene Carbonate as a Multifunctional Reagent.

Authors

Jiang Nan, Hanqing Zhang, Lanxin Zhu, Shilei Liu, Qiang Yan

Published in

The Journal of organic chemistry. Apr 03, 2025. Epub Apr 03, 2025.

Abstract

A divergent [5 + 1] cyclization reaction of o-aminobenzamides with vinylene carbonate has been developed, rapidly generating three types of cyclic molecules including quinazolinones, 2-methylquinazolinones, and 2,3-dihydroquinazolinones with high chemoselectivity. In this discovery, vinylene carbonate blooms as a multifunctional reagent to participate in cyclization. The potential of this new finding is further emphasized by assembling the benzothiazole heteroarene via the [4 + 1] version and tolerating bioactive units well.

PMID:
40179279
Bibliographic data and abstract were imported from PubMed on 04 Apr 2025.

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