Pyrrolidine Alkaloids and Polyketide Derivatives from the Marine-Derived Fungus Trichoderma harzianum ZN-4.

Authors

Chengzeng Zhou, Xunuo Li, Jiayu Pan, Yichao Ge, Xiaodan Wu, Bin Wu

Published in

The Journal of organic chemistry. Apr 05, 2025. Epub Apr 05, 2025.

Abstract

Two unusual alkaloids with furanopyrrolidine skeleton, harzianopyrrolidones A-B (1-2), four new compounds, harzianopyridone B (3), harzianopyrone (4), (R)-1-(3,5-dihydroxy-4-methylphenyl)-1-hydroxyhept-5E-en-2-one (5), and harzianopyrrolidone C (6), together with two known compounds (7-8) were isolated from a marine-derived fungus Trichoderma harzianum ZN-4. Structures of the isolated compounds were elucidated based on their HRESIMS data, extensive NMR spectroscopic analyses, NMR calculation in combination with DP4+, ECD calculations, and a single-crystal X-ray diffraction experiment. New compounds 1, 4, and 5 exhibited potential cardiomyocyte protective activity at concentrations ranging from 5 to 20 μM. In addition, 7 showed moderate inhibitory activity against Pestalotiopsis theae with an MIC value of 25 μg/mL.

PMID:
40186562
Bibliographic data and abstract were imported from PubMed on 06 Apr 2025.

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