Computer vision-guided rapid and precise automated cranial microsurgeries in mice.

Authors

Zahra S Navabi, Ryan Peters, Beatrice Gulner, Arun Cherkkil, Eunsong Ko, Farnoosh Dadashi, Jacob O Brien, Michael Feldkamp, Suhasa B Kodandaramaiah

Published in

Science advances. Volume 11. Issue 15. Pages eadt9693. Apr 11, 2025. Epub Apr 09, 2025.

Abstract

A common procedure that allows interfacing with the brain is cranial microsurgery, wherein small to large craniotomies are performed on the overlying skull for insertion of neural interfaces or implantation of optically clear windows for long-term cranial observation. Performing craniotomies requires skill, time, and precision to avoid damaging the brain and dura. Here, we present a computer vision-guided craniotomy robot (CV-Craniobot) that uses machine learning to accurately estimate the dorsal skull anatomy from optical coherence tomography images. Instantaneous information of skull morphology is used by a robotic mill to rapidly and precisely remove the skull from a desired craniotomy location. We show that the CV-Craniobot can perform small (2- to 4-millimeter diameter) craniotomies with near 100% success rates within 2 minutes and large craniotomies encompassing most of the dorsal cortex in less than 10 minutes. Thus, the CV-Craniobot enables rapid and precise craniotomies, reducing surgery time compared to human practitioners and eliminating the need for long training.

PMID:
40203110
Bibliographic data and abstract were imported from PubMed on 10 Apr 2025.

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