Clinical impact of very high-power-short-duration catheters on biomarkers after atrial fibrillation ablation.

Authors

Andrea Bernardini, Alessandro Paoletti Perini, Cristiano Salvatore Zaccaria, Davide Ciliberti, Umberto Signorini, Francesco Grossi, Raffaele Martone, Serena Fatucchi, Alenja Bertini, Anna Arretini, Lisa Innocenti, Irene Capecchi, Margherita Padeletti, Massimo Milli, Andrea Giomi

Published in

Journal of arrhythmia. Volume 41. Issue 2. Pages e70060. Epub Apr 09, 2025.

Abstract

Very high-power short-duration (vHPSD) catheters are associated with less irrigation fluid load than standard (STD RF) ablation catheters. However, the impact of this fluid reduction on biomarkers in pulmonary vein isolation (PVI) for atrial fibrillation (AF) remains unknown.
Biomarkers of heart failure, myocardial injury, and systemic inflammation status as Brain Natriuretic Peptide (BNP), high-sensitivity Troponin I (hsTnI), and C-reactive protein (CRP) were collected pre- and post-procedure of PVI for symptomatic AF. The study aimed to assess the impact of vHPSD catheter compared to an STD catheter (respectively irrigation of 8 vs. 15 mL/min during ablation) on biomarker alterations.
The study included 83 consecutive patients (59 males [71.1%], mean age 62.6 ± 11 years), with vHPSD catheters used in 53 cases (63.9%). No significant baseline differences were observed between groups.Fluid irrigation resulted in significantly lower with vHPSD catheter than STD RF (434.8 ± 105.6 vs. 806.6 ± 256.5 mL, p < .001). Correspondingly, BNP variation was significantly lower in the vHPSD group than in the STD RF group, both in absolute change (12 [IQR -9-47] pg/mL vs. 44.5 [IQR 21-88.7] pg/mL, p = .002) and percentage change (16.3 [IQR -13.2-108.6] % vs. 84.1 [IQR 32.5-172.1] %, p = .012). When considering absolute values, a statistically significant increase in BNP was found only in the STD catheter group (from 52 [IQR 35.2-113.5] to 113 [IQR 66.7-189.5] pg/mL, p < .001), whereas no significant increase was observed in the vHPSD group (p = .06). CRP levels increased post-PVI in both groups, but the delta was significantly lower in the vHPSD group (p = .025). No significant differences in post-procedural hsTnI were detected between groups.
The use of a vHPSD catheter is associated with reduced fluid irrigation and a correspondingly smaller increase in BNP, a biomarker indicative of fluid overload and heart failure.

PMID:
40207269
Bibliographic data and abstract were imported from PubMed on 10 Apr 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.