Ligand-Controlled Preparation of Aryl-Substituted Allenes Enabled by Nickel-Catalyzed Reductive Coupling of Secondary Propargylic Carbonates with Aryl Halides.

Authors

Ruotong Li, Jie Hu, Yonghao Xi, Hegui Gong, Weichen Huang

Published in

Organic letters. Apr 15, 2025. Epub Apr 15, 2025.

Abstract

Herein, we developed a new method for the synthesis of aryl-substituted allenes through a nickel-catalyzed reductive coupling reaction between secondary propargyl carbonates and aryl halides. By employing the dimethyl-1,10-phenanthroline ligand, we achieved a ligand-controlled, regioselective nickel-catalyzed reductive arylation, overcoming the structural limitations of propargyl electrophiles. Notably, this reaction exhibits exceptional functional group compatibility, rendering it particularly suitable for late-stage allenylation modifications of complex molecules.

PMID:
40233192
Bibliographic data and abstract were imported from PubMed on 16 Apr 2025.

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