Quantitative intra-arterial fluorescence angiography for direct monitoring of peripheral revascularization effects.

Authors

Harry G M Vaassen, Daan J Lips, Robert H Geelkerken, Bryan Wermelink

Published in

Journal of vascular surgery cases and innovative techniques. Volume 11. Issue 3. Pages 101770. Epub Mar 04, 2025.

Abstract

To investigate the feasibility of quantitative fluorescence angiography with intra-arterial dye injection (Q-iaFA) for intraoperative guidance during revascularization procedures in patients with chronic limb-threatening ischemia (CLTI).
In this observational cohort study, 14 patients with CLTI undergoing endovascular intervention were included. Q-iaFA was performed directly before and after revascularization. The parameters time to peak (TTP) and normalized peak slope (PS_norm) were derived from intensity-time curves that were measured on the plantar side of the foot in five regions of interest. The main outcome was defined as the change in these Q-iaFA parameters between pre- and postoperative measurements in the region of interest with the most inferior preoperative value. Expected impact of revascularization was classified into strong, moderate or absent, based on intraoperative radiographic imaging and the Trans-Atlantic Inter-Society II standards.
Q-iaFA was successful without complications in all patients. Revascularization impact was classified as strong in 8 (57%), moderate in 5 (36%), and as absent in 1 (7%) patients. In the strong impact group, a significant decrease in TTP and increase in PS_norm was observed (P = .004). The same trend was less pronounced in the moderate impact group, without statistical significance (P = .104 and P = .094). Conversely, in the patient with no expected revascularization impact, TTP increased and PS_norm decreased.
Q-iaFA is a feasible technique to evaluate peripheral tissue perfusion during vascular interventions. The extracted perfusion parameters are directly affected by revascularization of arterial lesions in patients with CLTI. This finding suggests that Q-iaFA may be useful to guide intraoperative decision making. Work is required to refine quantification strategies and relate Q-iaFA parameters to clinical outcomes.

PMID:
40236913
Bibliographic data and abstract were imported from PubMed on 16 Apr 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.