Association between conicity index (C-index), relative fat mass (RFM), and osteoarthritis (OA): evidence from NHANES 2003-2018.

Authors

Xiaodong Ren, Junxiang Wang, Jiachen Wang, Guoqiang Wang, Honghao Ren, Peng Xu, Mingyi Yang, Ke Xu

Published in

Lipids in health and disease. Volume 24. Issue 1. Pages 140. Apr 16, 2025. Epub Apr 16, 2025.

Abstract

Obesity is considered an important risk factor for osteoarthritis (OA), with conicity index (C-index), relative fat mass (RFM) are two novel anthropometric measures of obesity. To investigate the association between OA and these two indicators, we conducted this study.
We used data from the National Health and Nutrition Examination Survey (NHANES) to investigate the association between C-index, RFM, and OA. First, the participants were divided into two groups according to whether they had OA, and we compared the baseline characteristics of the two groups. Then, C-index and RFM were divided into quartiles (Q1, Q2, Q3, Q4) for multivariate regression analysis. Additionally, we applied restricted cubic spline (RCS) to assess whether the relationship is non-linear. Finally, we conducted a subgroup interaction analysis to investigate whether this relationship varies across different subgroups.
The study included 34,707 participants, with a weighted OA prevalence of 7.7%. Significant differences in C-index and RFM were observed between OA and non-OA groups. Treating C-index and RFM as categorical variables, logistic regression showed significantly higher OA risk in Q4 compared to Q1: for C-index, Q4 (OR = 1.60; 95% CI: 1.33-1.93; P < 0.001); for RFM, Q4 (OR = 2.07; 95% CI: 1.57-2.73; P < 0.001). The RCS results show that the relationship between C-index and OA is non-linear, while the relationship between RFM and OA is linear. Subgroup interaction analysis showed some interaction effects.
This study reveals detailed relationships between C-index, RFM, and OA, which may be better indicators of obesity in assessing OA risk.

PMID:
40241060
Bibliographic data and abstract were imported from PubMed on 17 Apr 2025.

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