Preparation and use of SER/GLU-based DES as a novel and potent catalyst for the green synthesis of pyrazolopyranopyrimidines.

Authors

Nastaran Dehnokhalaji, Davood Habibi, Arezo Monem, Afagh Ranjbaran

Published in

Scientific reports. Volume 15. Issue 1. Pages 13583. Apr 19, 2025. Epub Apr 19, 2025.

Abstract

Based on the eutectic point phase diagram, a novel natural deep eutectic solvent (SER/GLU-DES) was prepared by a mixture of one mole of serine (SER) and one mole of glutaric acid (GLU), and characterized by various techniques. Then, it was used as a novel and potent catalyst for the synthesis of two sets of biologically important pyrazolopyranopyrimidines via a one-pot four-component condensation reaction of ethyl acetoacetate, hydrazinehydrate/ phenylhydrazine, barbituric acid and aldehydes at 70 °C, in solvent-free conditions.

PMID:
40253437
Bibliographic data and abstract were imported from PubMed on 20 Apr 2025.

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