Pharmacokinetics of Oleracrylimide E in Rats Plasma Using UHPLC/-ESI-Q-TOF/MS.

Authors

Zheming Ying, Kaiyun Jiang, Chengyu Wang, Hongzhe Zhang, Junjie Yao, Yingdai Zhao, Xixiang Ying, Yanling Ren

Published in

Biomedical chromatography : BMC. Volume 39. Issue 6. Pages e70067.

Abstract

Oleracrylimide E, a new alkaloid from Portulaca oleracea L., shows significant bioactivity. Then, the pharmacokinetics of this alkaloid after its intravenous administration at dose of 2.0 mg/kg body weight in rat plasma was evaluated using UHPLC with vitexin-2″-O-rhamnoside as an internal standard (IS). The UHPLC-ESI-Q-TOF/MS method was applied to investigate the metabolism of Oleracrylimide E in rats in response to the immediate conversion of Oleracrylimide E into other metabolites after its oral administration. As a result, a total of 16 metabolites of Oleracrylimide E were identified in the plasma, urine, and fecal of the experimental rats.

PMID:
40254553
Bibliographic data and abstract were imported from PubMed on 21 Apr 2025.

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