Phthalide mono- and dimers from the rhizomes of Angelica sinensis and their anti-inflammatory activities.

Authors

Hongyan Wen, Sheng Li, Yu Zhang

Published in

Natural products and bioprospecting. Volume 15. Issue 1. Pages 26. Apr 24, 2025. Epub Apr 24, 2025.

Abstract

Three pairs of enantiomeric phthalide dimers, including two new ones, angesicolides A (1) and B (2), and a new phthalide monomer (3), were obtained from the rhizomes of Angelica sinensis. Their structures were established through spectroscopic methods, quantum calculations, and chiral HPLC analysis. Compounds 1 and 2 were [2 + 2] and [4 + 2] cycloadducts of phthalide monomers, and their hypothetical biogenetic origin was proposed. Compounds 2, (+)-2, (-)-2, 4, (+)-4, and (-)-4 exhibited significant inhibitory activity against NO production with IC₅₀ values range from 1.23 to 5.55 μM.

PMID:
40272678
Bibliographic data and abstract were imported from PubMed on 24 Apr 2025.

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