Catalytic Generation of o-Quinone Dimethides by a Nondiazo Approach via Donor/Donor Platinum Carbenes.

Authors

Jun-Jie Hao, Tao Jiang, FuJunyang Wu, Hejiang Luo, Rong-Tao Li

Published in

Organic letters. Apr 27, 2025. Epub Apr 27, 2025.

Abstract

A platinum-catalyzed reaction of enynones with various dienophiles has been developed for the construction of tetrahydronaphthalene derivatives, which undergo a Diels-Alder reaction process with platinum carbenes and o-quinone dimethide (o-QDM) intermediates. In this protocol, an alkoxy-substituted conjugated enynone is used as a nondiazo carbene precursor for the generation of o-QDMs, thereby extending the methods available for the generation of o-QDMs. The reaction is characterized by its high atom economy, high diastereoselectivity, and broad substrate scope.

PMID:
40287838
Bibliographic data and abstract were imported from PubMed on 27 Apr 2025.

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