Fluctuating or progressive hearing loss in the middle-to-high frequencies may suggest the neurotologic endotype of perilymphatic fistula without antecedent traumatic events.

Authors

Han Matsuda, Yukihide Maeda, Tomoyasu Kitahara, Masafumi Sawada, Hiroe Kudo, Kei Sakamoto, Atsuya Takayama, Tetsuo Ikezono

Published in

Frontiers in neurology. Volume 16. Pages 1571379. Epub Apr 14, 2025.

Abstract

Idiopathic sudden sensorineural hearing loss (ISSNHL) is a common clinical condition. Recent studies indicate that approximately 20% of ISSNHL cases may involve perilymphatic fistula (PLF). The detection of Cochlin-tomoprotein (CTP) in middle-ear lavage samples confirms the diagnosis of PLF.
To clarify the clinical characteristics of inner ear-related symptoms in patients with PLF who lacked any antecedent traumatic events prior to symptom onset.
We retrospectively reviewed clinical records and CTP test results in 769 cases from 70 hospitals in Japan.
Among these cases, 204 had no history of antecedent events. CTP-positive findings were more frequently observed in patients exhibiting fluctuating and/or progressive hearing loss than in those without these symptoms (p < 0.05, Fisher's exact test). The odds of a positive CTP test did not differ between patients with and without vestibular symptoms, nystagmus, a fistula sign, a popping sensation, or streaming water-like tinnitus (p > 0.05, Fisher's exact test). The CTP positivity rate was highest in patients with a high-frequency sloping audiogram.
Fluctuating or progressive hearing loss in the middle-to-high frequencies may reasonably suggest PLF in the absence of antecedent traumatic events.

PMID:
40297856
Bibliographic data and abstract were imported from PubMed on 29 Apr 2025.

Read full publication at:
Please sign in to see all details.

Stats

1-terrible, 9-excellent. How would you rate this publication? Sign in in to submit your rating.

Post a comment

You need to be signed in to post comments. You can sign in here.

Comments

There are no comments yet.